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Worker process of our ASP.NET application runs as DefaultAppPool which does not have access to registry keys of logged-on user and cannot debug VBScript invoked from C#. Can I add registry keys to DefaultAppPool user account?

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DefaultAppPool is not an account, it's an app pool. Inside that app pool you can define which account it runs under (advanced settings / Identity)

Assign it a windows account that has sufficient privileges. Normally you would create a windows account especially for the purpose.


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