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I have a binded DataGridView that contains a large amount of data. The problem is that some cells has to be ReadOnly and also when the user navigates with TAB or ENTER between cells, the ReadOnly cells should be bypassed. What's the best way of making some specific cells ReadOnly imediatly after loadging?

Looping through cells after I set DataSource is not a good idea taking in consideration that the grid has a large amount of data. Also, making the cell ReadOnly on CellEnter does not work because when navigating with TAB key I have to already know if the next cell is ReadOnly or not.

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Try to make the column rather than individual cells readonly before binding the data:

this.dgrid.Columns["colName"].ReadOnly = true;

If you need to do for individual cells within the column, then you will have to loop and set them like this:

this.dgridvwMain.Rows[index].Cells["colName"].ReadOnly = true;

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